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Skin / Beauty

Melanotan II Protocol

Updated 2mo ago 4 min read 388+ helpful Calculator
Beginner setup

Vial sizes vary by vendor. Smaller bottles are usually 3 mL; larger bottles are often 10 mL. Match the label on the vial you actually bought, then use the calculator below if you need to adjust.

Vial strength 10 mg
Bottle format often 3 mL
BAC water 3 mL
Concentration 3.33 mg/mL

Overview

Melanotan II activates MC1R to produce melanin without UV exposure — the ‘tanning peptide’. It also hits MC4R, which is why it shares side effects (and a chemical family) with PT-141. Dose discipline is non-negotiable: never exceed 2 mg/day.

Preparation

Reconstitute a 10 mg vial with 3 mL of bacteriostatic water (BAC) for a 3.33 mg/mL concentration. Refrigerate and use within 1–2 weeks once mixed.

VialBACConcentration
10 mg3 mL3.33 mg/mL

Protocol

PeriodDoseUnits (@ 3.33 mg/mL)Frequency
Week 1250 mcg (0.25 mg)7.5 units (0.075 mL)1x/day
Week 2500 mcg (0.5 mg)15 units (0.15 mL)1x/day
Week 3750 mcg (0.75 mg)22.5 units (0.225 mL)1x/day
Weeks 4–81,000 mcg (1 mg)30 units (0.30 mL)1x/day

Cycle

8-week loading phase daily, then 1–2 maintenance injections per week to hold color. Never exceed 2 mg/day — mega-doses are where the serious toxicity reports live.

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Dosing Calculator

10 mg + 3 mL · suggested 250 mcg
10 mg vial · 3 mL BAC
102030405060708090100
80.08 mL
Concentration3.33 mg/mL
Selected dose0.25 mg (250 mcg) = 8 units
1 unit = 0.01 mL on a U-100 syringe. Doses round to the nearest unit.