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Immune / Anti-Inflammatory

LL-37 Protocol

Updated 6d ago 4 min read 207+ helpful Calculator
Beginner setup

Vial sizes vary by vendor. Smaller bottles are usually 3 mL; larger bottles are often 10 mL. Match the label on the vial you actually bought, then use the calculator below if you need to adjust.

Vial strength 5 mg
Bottle format often 3 mL
BAC water 3 mL
Concentration 1.67 mg/mL

Overview

LL-37 is the human cathelicidin antimicrobial peptide — part of the innate immune system. It kills pathogens, modulates inflammation, and accelerates wound closure. Sensitive compound: handle gently, titrate slowly.

Preparation

Reconstitute a 5 mg vial with 3 mL of bacteriostatic water (BAC) for a ~1.67 mg/mL concentration. Roll gently to dissolve — never shake or agitate.

VialBACConcentration
5 mg3 mL1.67 mg/mL

Protocol

PeriodDoseUnits (@ 1.67 mg/mL)Frequency
Week 150 mcg3 units (0.03 mL)1x/day
Week 2100 mcg6 units (0.06 mL)1x/day
Week 3150 mcg9 units (0.09 mL)1x/day
Week 4200 mcg12 units (0.12 mL)1x/day
Week 5250 mcg15 units (0.15 mL)1x/day
Week 6300 mcg18 units (0.18 mL)1x/day
Week 7350 mcg21 units (0.21 mL)1x/day
Week 8400 mcg24 units (0.24 mL)1x/day

Cycle

Weekly-titrated 8-week cycles. The slow ramp matters — LL-37 is potent and over-enthusiastic starts are the classic mistake.

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Dosing Calculator

5 mg + 3 mL · suggested 50 mcg
5 mg vial · 3 mL BAC
102030405060708090100
30.03 mL
Concentration1.67 mg/mL
Selected dose0.05 mg (50 mcg) = 3 units
1 unit = 0.01 mL on a U-100 syringe. Doses round to the nearest unit.